Careers

hC Bioscience, Inc.

hC Bioscience is pioneering tRNA drug products which include a variety of delivery approaches. We are seeking a highly motivated Chemist to design and synthesize oligonucleotide conjugates and lipid conjugates to discover and develop enhanced delivery options for our tRNA platform. The successful candidate will work cross-functionally with tRNA discovery scientists and formulation scientists to create conjugates that provide for targeting and/or increased cytosolic entry and closely with translational biology to evaluate performance in vitro and in vivo.

SUMMARY

hC Bioscience is pioneering tRNA drug products which include a variety of delivery approaches.  We are seeking a highly motivated Chemist to design and synthesize oligonucleotide conjugates and lipid conjugates to discover and develop enhanced delivery options for our tRNA platform.   The successful candidate will work cross-functionally with tRNA discovery scientists and formulation scientists to create conjugates that provide for targeting and/or increased cytosolic entry and closely with translational biology to evaluate performance in vitro and in vivo. 

 RESPONSIBILITIES:

• Identify small molecules, peptides, and natural products from the field of targeted delivery and/or cell penetration, adapt them for use with tRNA, and establish proprietary constructs for enhanced delivery of tRNA therapeutics
• Define linker moieties or pre-conjugated phosphoamidites for CROs to incorporate into RNA-based oligonucleotides to enable the discovery of efficient and bioactive conjugation
• Design, synthesize, and purify novel conjugates of oligonucleotides
• Work with analytical chemistry to characterize conjugated products
• Serve as a chemistry expert on oligonucleotide modification
• Assist with the development of project strategy
• Support and engage with strategic partnerships regarding targeted delivery
• Facilitate LNP formulation team use of lipid/PEG-lipid conjugates
• Author invention records and patent filings
• Maintain an electronic notebook and present plans and key findings at meetings

QUALIFICATIONS:

• Ph.D. in organic chemistry, biochemistry or related field with 3-8 years of relevant post-doctoral industry or academic experience
• Hands-on experience in the chemistry of modifying, conjugating or synthesizing nucleic acids, peptides or proteins

·       Versatility in multi-step organic synthesis including purification methods

• Strong communication, critical thinking, and organizational skills.
• Ability to effectively plan and organize complex work activities and prioritize tasks.

POSITION: Full-Time, Exempt

We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, national origin, disability status, protected veteran status or any other characteristic protected by law.