Senior/Principal Research Associate, Process Development

Position Summary:

hC Bioscience is dedicated to improving the lives of patients with the development of first-in-class tRNA-based therapeutics targeting protein dysfunction. hC Bioscience’s innovative approach to precision protein editing has the potential to treat genetically defined conditions which account for 10-15% of all genetic disease patients.

tRNA as a molecule can be viewed as a platform from which many variations can be implemented to treat a wide variety of diseases. As part of the CMC team, you will be responsible for developing and implementing process development activities to meet program deadlines. You must be familiar with a wide range of separation and purification techniques such as anion exchange and tangential flow filtration.  The ideal candidate will have experience with protein and polynucleotide downstream processing, including in-process analytics.

Key Responsibilities:

• Independently conduct complex experiments within a project scope, exercising judgment to evaluate a variety of technical factors, and obtain optimum solutions.
• Independently provides work group with technical guidance and problem resolution related to methods, procedures and processes.
• Utilizes assigned literature to increase knowledge base and implement improvements.
• Prepares and presents technical information at meetings. Contributes technical information for company patent efforts.
• Troubleshoots non-routine methods, instrumentation, or software issues and recommends systems, processes, or changes within project scope to meet objectives
• Record experimental data in an electronic laboratory notebook.

Qualifications & Experience:

• A BS with 5-10 years of experience or an M.S. with 2+ years’ industry experience, or equivalent.
• Experience with early-stage (PhI and PhII) process development, including technology transfer to CDMOs.
• Experience with lipid nanoparticles or antibody-drug conjugates is advantageous.
• Skilled in downstream processing such as chromatography and tangential flow filtration is a must.
• Must have excellent organizational and communication skills.

We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, national origin, disability status, protected veteran status or any other characteristic protected by law.

Please submit your cover letter and resume to careers@hcbioscience.com.